Browsing by Author "Bothra, Asim K"

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    Bioinformatics of codon usage pattern in pathogenic proteobacteria Burkholderia mallei
    (University of North Bengal, 2010-03) Ghosh, Manash K; Bothra, Asim K; Sen, Arnab
    Burkholderia mallei are pathogenic gram negative ß Proteobacteria those are available in Africa, Asia, Middle East, Central and South America and abundantly known as the causal organism of glanders. In this study, the synonymous patterns of four Burkholderia mallei (Burkholderia mallei ATCC 23344, Burkholderia mallei NCTC 10229, Burkholderia mallei NCTC 10247, Burkholderia mallei SAVP1) genome were compared and analyzed to each other. It was observed that Burkholderia mallei have high G+C content and moderately biased. Using cogon adaptation index (CAI) as a numerical estimator of gene expression level where ribosomal protein coding genes were considered as a reference of highly expressed genes. Here, we also studied the functional analysis of the PHX genes, gene expression level correspondence analysis and horizontally transferred pathogenicity related genes activity. COGs are also associated with metabolism especially those linked to carbohydrate metabolism and amino acid transport.
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    Bioinformatics of pathogenic food bacteria
    (University of North Bengal, 2012-03) Mondal, Uttam K; Sen, Arnab; Bothra, Asim K
    Cholera is a fatal water borne disease caused by Vibrio cholerae. The primary symptoms include profuse watery diarrhea, muscle cramps and vomiting of clear fluid leading to rapid dehydration and electrolyte imbalance. and death in some cases. The causal organism i.e. Vibrio cholerae was first isolated by an Italian anatomist. Filippo Pacini in 1854. With the advent of genome sequencing technology, several Vibrio cholerae strains have been sequenced and available in public domain. This provided the opportunity for the scientists to study their genome in details. In the present review we have looked into the genetics of food pathogen as a whole, with special reference to research on V. cholerae. We have also critically reviewed various aspects of Bioinformatics like codon usage patterns, phylogenetic studies, studies on structural bioinformatics etc. on food borne bacteria. We are confident that the present review will help the researchers of food pathogenic biology to obtain valuable information about the present status of bioinformatics of food pathogenic bacteria and future outlook of these aspects.